3-trimethylsilyl-2-propynoic acid
3-(Trimethylsilyl)propionic acid
CAS: 5683-31-8
Molecular Formula: C6H10O2Si
3-trimethylsilyl-2-propynoic acid - Names and Identifiers
3-trimethylsilyl-2-propynoic acid - Physico-chemical Properties
| Molecular Formula | C6H10O2Si |
| Molar Mass | 142.23 |
| Density | 1.006±0.06 g/cm3(Predicted) |
| Melting Point | 47-49 °C (lit.) |
| Boling Point | 105-110 °C/10 mmHg (lit.) |
| Flash Point | 205°F |
| Solubility | Soluble in methanol. |
| Vapor Presure | 0.046mmHg at 25°C |
| Appearance | solid |
| Color | White to Almost white |
| BRN | 1755674 |
| pKa | 1.88±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | 4: no reaction with water under neutral conditions |
| Refractive Index | 1.452 |
3-trimethylsilyl-2-propynoic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 1-10 |
| TSCA | No |
| HS Code | 29319090 |
3-trimethylsilyl-2-propynoic acid - Introduction
3-(Trimethylsilyl)propionic acid is an organic compound with the chemical formula C8H16O2Si. It is a colorless liquid with a special smell.
The main use of this compound is as a material for organic synthesis, especially as a ligand in organometallic catalyzed reactions. It can coordinate with the metal to form a stable complex, and participate in reactions similar to C- H activation and C- C bond formation. In addition, it can also be used as an intermediate for the preparation of other organosilicon compounds.
The preparation of 3-(Trimethylsilyl)propionic acid is mainly carried out by a two-step reaction. First, 3-propargyl alcohol is reacted with hydrochloric acid to produce 3-chloropropargyl alcohol. The 3-chloropropargyl alcohol is then reacted with trimethylchlorosilane to give the 3-(Trimethylsilyl)propionic acid.
Regarding safety information, the 3-(Trimethylsilyl)propionic acid is generally relatively safe under normal operating conditions. However, it is a flammable liquid that can cause a fire or explosion in the presence of high temperature, open flame or oxygen. Therefore, it is necessary to pay attention to fire prevention measures during use or storage and ensure good ventilation. In addition, avoid contact with strong oxidants, avoid inhalation or skin contact. In case of inhalation or contact, seek medical attention immediately. Wear appropriate personal protective equipment such as gloves and goggles when handling.
The main use of this compound is as a material for organic synthesis, especially as a ligand in organometallic catalyzed reactions. It can coordinate with the metal to form a stable complex, and participate in reactions similar to C- H activation and C- C bond formation. In addition, it can also be used as an intermediate for the preparation of other organosilicon compounds.
The preparation of 3-(Trimethylsilyl)propionic acid is mainly carried out by a two-step reaction. First, 3-propargyl alcohol is reacted with hydrochloric acid to produce 3-chloropropargyl alcohol. The 3-chloropropargyl alcohol is then reacted with trimethylchlorosilane to give the 3-(Trimethylsilyl)propionic acid.
Regarding safety information, the 3-(Trimethylsilyl)propionic acid is generally relatively safe under normal operating conditions. However, it is a flammable liquid that can cause a fire or explosion in the presence of high temperature, open flame or oxygen. Therefore, it is necessary to pay attention to fire prevention measures during use or storage and ensure good ventilation. In addition, avoid contact with strong oxidants, avoid inhalation or skin contact. In case of inhalation or contact, seek medical attention immediately. Wear appropriate personal protective equipment such as gloves and goggles when handling.
Last Update：2024-04-10 22:29:15
